CV
Timothy Steven Wessler
Positions:
2023 January – present
University of Colorado (Boulder)
Research Associate
Department of Applied Mathematics
Advisor: Nancy Rodriguez
2020 April – September 2022
Postdoctoral Researcher
University of North Carolina (Chapel Hill)
Department of Mathematics and Department of Microbiology and Immunology
Advisors: M. Gregory Forest and Samuel K. Lai
2017 June – 2020 March
Postdoctoral Research Fellow
University of Michigan (Ann Arbor)
Department of Chemical Engineering and Department of Microbiology and Immunology
Advisors: Jennifer J. Linderman and Denise E. Kirschner
Education:
Ph.D. University of North Carolina at Chapel Hill
(2017) Mathematics, Certificate in Big Data
Ph.D. Advisor: M. Gregory Forest
B.S. North Carolina State University
(2012) Mathematics, summa cum laude
Honors Advisor: Mansoor A. Haider
Publications:
*Denotes co-1st author
(2016) Wessler T*, Chen A*, McKinley SA, Cone R, Forest MG, Lai SK. Using computational modeling to optimize the design of antibodies that trap viruses in mucus. ACS Infect. Dis., 2 (1):82–92, DOI: 10.1021/acsinfecdis.5b00108, PMID: 26771004
http://pubs.acs.org/doi/abs/10.1021/acsinfecdis.5b00108
(2016) Kapustina M*, Tsygankov D*, Zhao J*, Wessler T, Yang X, Chen A, Roach N, Elston TC, Wang Q, Jacobson K, Forest MG. Modeling the excess cell surface stored in a complex morphology of bleb-like protrusions. PLoS Comput Biol., 12(3):e1004841, DOI: 10.1371/journal.pcbi.1004841, PMID: 27015526
http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004841
(2017) Newby J, Schiller JL, Wessler T, Edelstein J, Forest MG, Lai S.K A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors. Nat Commun., 8(1):833, DOI: 10.1038/s41467-017-00739-6, PMID: 29018239
https://www.nature.com/articles/s41467-017-00739-6
(2018) McSweeney MD*, Wessler T*, Price LSL, Ciociola EC, Herity LB, Piscitelli JA, Zamboni WC, Forest MG, Cao Y, Lai SK. A minimal physiologically based pharmacokinetic model that predicts anti-PEG antibody-mediated clearance of PEGylated drugs in human and mouse. J Control Release, 284:171-178, DOI: 10.1016/j.jconrel.2018.06.002, PMID: 29879519
https://www.sciencedirect.com/science/article/pii/S0168365918303286
(2018) Cicchese JM*, Evans S*, Hult C*, Joslyn LR*, Wessler T*, Millar JA, Marino S, Cilfone NA, Mattila JT, Linderman JJ, Kirschner DE. Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology. Immol Rev., 285(1):147-167, DOI: 10.111/imr.12671, PMID: 30129209
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292442/pdf/nihms-996256.pdf
(2019) Renardy M, Wessler T, Blemker S, Linderman J, Peirce S, Kirschner D. Data-driven model validation across dimensions. Bulletin of Mathematical Biology. DOI: 10.1007/s11538-019-00590-4
https://link.springer.com/article/10.1007/s11538-019-00590-4
(2019) Xu F, Newby JM, Schiller JL, Schroeder HA, Wessler T, Chen A, Forest MG, Lai SK. Modeling barrier properties of intestinal mucus reinforced with IgG and secretory IgA against motile bacteria. ACS Infect. Dis., DOI: 10.1021/acsinfecdis.9b00109, PMID: 31268295
https://pubs.acs.org/doi/10.1021/acsinfecdis.9b00109
(2019) McSweeney MD*, Price LSL*, Wessler T, Ciociola EC, Herity LB, Piscitelli JA, DeWalle AC, Harris TN, Chan AKP, Saw RS, Hu P, Jennette JC, Forest MG, Cao Y, Montgomery SA, Zamboni WC, Lai SK. Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated therapeutics by preinfusion with high molecular weight free PEG. J Control Release, DOI: 10.1016/j.jconrel.2019.08.017, PMID: 31454530
https://www.sciencedirect.com/science/article/pii/S0168365919304973
(2020) Menezes B, Cilliers C, Wessler T, Thurber GM, Linderman JJ. An Agent-Based Systems Pharmacology Model of the Antibody Drug Conjugate Kadcyla to Predict Efficacy of Different Dosing Regimens. AAPS J, DOI: 10.1208/s122448-019-0391-1, PMID: 31942650
https://doi.org/10.1208/s12248-019-0391-1
(2020) Wessler T, Joslyn LR, Borish HJ, Gideon HP, Flynn JL, Kirschner DE, Linderman JJ. A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination. PLoS Comput Biol., 16(5): e1007280, DOI: 10.1371/jounal.pcbi.1007280
https://doi.org/10.1371/journal.pcbi.1007280
(2021) Talkington AM, Wessler T, Lai SK, Cao Y, Forest MG. Experimental Data and PBPK Modeling Quantify Antibody Interference in PEGylated Drug Carrier Delivery. Bulletin of Mathematical Biology. DOI: 10.1007/s11538-021-00950-z
https://link.springer.com/article/10.1007/s11538-021-00950-z
(2022) Talkington A, McSweeney M, Wessler T, Rath M, Zibo L, Zhang T, Yuan H, Cao Y, Forest MG, Lai SK. A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes. J Control Release, DOI: 10.1016/j.jconrel.2022.01.022, PMID: 35066099
https://www.sciencedirect.com/science/article/abs/pii/S0168365922000360
(2022) Chen A*, Wessler T*, Daftari K, Hinton K, Boucher RC, Pickles R, Freeman R, Lai SK, Forest MG. Modeling insights into SARS-CoV-2 respiratory tract infections prior to immune protection. Biophys J., DOI: 10.1016/j.bpj.2022.04.003, PMID: 35378080
https://www.cell.com/biophysj/fulltext/S0006-3495(22)00277-6
(2022) Chen A, Wessler T, Forest MG. Antibody protection from SARS-CoV-2 respiratory tract exposure and infection. J. Theor. Biol., DOI: 10.1016/j.jtbi.2022.111334
https://www.sciencedirect.com/science/article/pii/S0022519322003253
(2023) Travis AM, Manocha S, Wessler T, Willer JR, Skiba NP, Pearring JN. Disrupting the cillary gradient of active Arl3 affects rod photoreceptor nuclear migration. eLife, DOI: 10.7554/eLife.80533, PMID: 36598133
https://elifesciences.org/articles/80533
(2023) Pearson J, Wessler T, Chen A, Boucher RC, Freeman R, Lai SK, Pickles R, Forest MG. Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48h post infection. J. Theor. Biol., DOI: 10.1016/j.jtbi.2023.111470
https://www.sciencedirect.com/science/article/pii/S0022519323000668
(2024) Zhang L, Cao H, Medlin K, Pearson J, Aristotelous AC, Chen A, Wessler T, Forest MG. Computational Modeling Insights into Extreme Heterogeneity in COVID-19 Nasal Swab Data. Viruses, DOI: 10.3390/v16010069
https://www.mdpi.com/1999-4915/16/1/69
Manuscripts Submitted:
Teaching:
APPM 2360: Introduction to Differential Equations with Linear Algebra, Fall 2023 (CU—Boulder)
MATH 528L: Mathematical Methods I Lab, Fall 2014 (UNC—Chapel Hill)
MATH 130: Precalculus Mathematics, Spring 2014 (UNC—Chapel Hill)
MATH 130: Precalculus Mathematics, Fall 2013 (UNC—Chapel Hill)
Talks:
2023 November 28, Applied Mathematics Colloquium, University of Colorado, Boulder, CO
2017 March 18-19, SIAM SEAS Conference, Florida State University, Tallahassee, FL
2017 January 7, Joint Mathematics Meeting, Atlanta, GA
2016 December 3, The Triangle Area Graduate Mathematics Conference, UNC, Chapel Hill, NC
2016 September 26, Graduate Mathematics Association (GMA) Seminar, UNC, Chapel Hill, NC
2016 July 11, SIAM Conference on the Life Sciences, Boston, MA
2015 December 7, GMA Seminar, UNC, Chapel Hill, NC
2015 June 30, Society for Mathematical Biology, Georgia State University, Atlanta, GA
2012 April 25, SUM Series Honors Talks, North Carolina State University, Raleigh, NC
Posters:
2018 July 9, Society for Mathematical Biology, University of Sydney, Sydney, NSW, Australia
2018 February 19, Mathematical Biosciences Institute Host-Pathogen Dynamics Workshop, Ohio State University, Columbus, OH
2018 January 31, University of Michigan Center for Systems Biology Symposium, University of Michigan, Ann Arbor, MI
2017 July 17, Society for Mathematical Biology, University of Utah, Salt Lake City, UT
2016 May 22, BAMM! Biology and Medicine through Mathematics, Virginia Commonwealth University, Richmond, VA
2016 April 8, UNC Academic Research Conference, University of North Carolina, Chapel Hill, NC
2012 April 11, NC State Undergraduate Research Symposium, North Carolina State University, Raleigh, NC